MULTIPLE VIRTUAL SCREENING APPROACHES FOR FINDING NEW HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE INHIBITORS: STRUCTURE-BASED SCREENS AND MOLECULAR DYNAMICS FOR THE PURSUE OF NEW POLY PHARMACOLOGICAL INHIBITORS

Abstract The RNA polymerase NS5B of Hepatitis C virus (HCV) is a well-characterised drug target with an active site and four allosteric binding sites.This work presents a workflow for virtual screening and its application to Drug Bank screening targeting the Hepatitis C Virus (HCV) RNA polymerase non-nucleoside binding sites.Potential polypharmacol

Steven J Greco1, Pranela Rameshwar21Graduate School of Biomedical Sciences; 2Department of Medicine, Division of Hematology/Oncology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, USAAbstract: The therapeutic utilization of stem cells has been ongoing for several decades, principally in the form of bone m

HAPPY mapping was designed to pursue the analysis of approximately random HAPloid DNA breakage samples using the PolYmerase chain reaction for mapping genomes.In the present study, we improved the method and integrated two other molecular techniques into the process: whole genome amplification and the Sequenom SNP (single nucleotide polymorphism) g

Abstract To examine the effects of short duration stress management training (SMT) on LED Candle self-perceived depression, anxiety and stress in male automotive assembly workers, 118 male automotive workers from Pekan, Pahang (n = 60, mean age = 40.0 years, SD = 6.67) and Kota Bharu, Kelantan (n = 58, mean age = 38.1 years, SD = 5.86) were assigne

The Police Mediated Legal and Social Assistance pilot program was piloted in two districts in Hanoi, Vietnam, between 2018 and 2020.It aimed to strengthen Floor Lamp the collaboration between law enforcement and the health and labour sectors and to strengthen the capacity of community services to divert people who use drugs from compulsory resident